California has reported the country’s first positive hantavirus rodent detection of 2026, a stark reminder that this relatively rare but deadly disease remains an active threat. The disease gained renewed attention last year following the tragic death of Betsy Arakawa, wife of legendary actor Gene Hackman, from hantavirus pulmonary syndrome (HPS).

“Rodent-borne diseases didn’t disappear after last year’s tragedy,” said Dr. Jim Fredericks, board-certified entomologist and SVP of public affairs at the National Pest Management Association (NPMA). “The danger is real, especially during the colder months as rodents push their way indoors, but early prevention and working with a pest control professional are key to protecting your health.”
Yet most Americans remain unaware of rodent health risks. In a survey conducted online by The Harris Poll on behalf of NPMA, only 28% of Americans are aware that rodents can carry diseases.
While deer mice spread hantavirus, other rodents can transmit more than 35 diseases to humans, including leptospirosis (liver and kidney damage), salmonellosis (food poisoning), hemorrhagic fever with renal syndrome (kidney failure), and rat-bite fever. Rodents also trigger allergies and asthma, contaminate food, and cause structural damage.
To protect against rodent-borne diseases, the NPMA encourages you to:
- Never sweep or vacuum rodent droppings. This can release deadly particles into the air. Soak with bleach-based disinfectant, then wipe or mop the area.
- Seal cracks and holes. Rodents can squeeze through openings as small as a dime.
- Store food in airtight containers.
- Remove clutter where mice and other rodents build nests.
If you suspect rodents in your home or business, the NFPA urges you to contact a qualified pest control professional immediately to safely remove and prevent them from returning.
ALSO READ: How to Launch an Integrated Pest Management Program
